A plan brokered by FIFA puts Motsepe in charge with Senegalese Augustin Senghor and Mauritanian Ahmed Yahya becoming vice-presidents and Anouma a special advisor.
Motsepe will be the first South African to lead CAF, following in the footsteps of two Egyptians, a Sudanese, an Ethiopian, a Cameroonian and a Malagasy.
Unlike previous African football leaders, who came from national association backgrounds, his connection with the sport stems from owning record 2016 African champions Mamelodi Sundowns.
Until a recent rule change, the supporter of Spanish giants Barcelona would not have been eligible to become president as candidates had to be CAF executive committee members.
The 59-year-old began his working life as a lawyer, switched to mining, and is now involved in many businesses. Forbes magazine estimates his personal wealth at $2.9 billion (2.4 billion euros.